Position an oven rack in the middle. Preheat the oven to 400°F (200°C). Line a baking sheet with parchment paper. Place the salmon, skin side down, on the prepared baking sheet.
In a small bowl, mix mayonnaise, Dijon mustard, garlic, Italian seasoning, salt, and pepper.
Spread the mayonnaise mixture over the salmon.
In a separate small bowl, combine breadcrumbs, Parmesan cheese, and parsley. Pour in the melted butter. Season with 3/4 teaspoon of salt and 1/3 teaspoon of pepper, adjusting to taste. Mix well and allow the breadcrumbs to absorb the butter.
Spread the breadcrumb mixture over the salmon, gently pressing it onto the top of the fillet to ensure full coating.
Bake uncovered for 12-15 minutes, adjusting time based on fillet thickness. Look for a golden crust and ensure the salmon is cooked and flakes easily with a fork.
Serve with lemon wedges; add a squeeze of lemon if desired. Pair with a salad, steamed vegetables, rice, or mashed potatoes for a complete meal.
Enjoy!